Progress in Colorectal Cancer Gene Survivin.doc

 PAGE \* MERGEFORMAT 13 Progress in Colorectal Cancer Gene Survivin [Keywords:] colorectal cancer Survivin gene Colorectal cancer (colorectal cancer, CRC) ranks fifth in China common malignancy, its incidence and mortality rates have increased year by year trend, the age of onset has improved markedly. The occurrence of colorectal cancer development is a genetic change and involve a variety of multi-stage complex process of carcinogenesis. Survivin is the inhibitor of apoptosis protein (inhibitor of apoptosis protein, IAP) family, a member of the human Survivin gene is Ambrosini is equal to 1997 through the effector cell protease receptor-1 (effector cell prctease receptor  1, EPR  1) cDNA in the human genomic library of hybrid screening isolated [1]. In recent years, a large number of studies have shown that colorectal cancer with positive expression of Survivin in colorectal cancer incidence and metastasis are certain relations [2]. In this paper, Survivin gene structure, distribution, and its occurrence in colorectal role in the process are reviewed. The molecular structure of 1 Survivin Survivin gene length 14.7kb, located on chromosome 17q25, has four exons and three introns, structure and the other members of the IAP family, different. Other members of the IAP family structure contain 2 to 3 in series containing cysteine / histidine baculovirus IAP repeat regions (BIR), the adjacent carboxyl-terminal contains a ring finger-like structure, but the Survivin in N-terminal structure contains only one BIR domain, by an anti-parallel β -sheet layer and 14 small α -helix structure and composition, containing an important role in inhibiting apoptosis of amino acid residues Tip67, Pro33 and Cys84. Carboxyl-terminal does not contain RING finger-like structure, and substituting a 40 amino acids length of 6.5nm gender α -helix structure, the positioning of the main regulating Survivin distribution [3]. Survivin has five kinds of isomers, Stauber RH, etc. [4]