Propofol anesthesia in the clinical application of orthopedic surgery.docVIP

Propofol anesthesia in the clinical application of orthopedic surgery Propofol (propofol), its chemical name 2,6 - bis-isopropyl phenol, is commonly used in clinical anesthesia induction, maintenance of anesthesia, ICU sedation in critically ill patients a new type of rapid, short-acting intravenous anesthetics. It has a rapid onset of anesthesia, recovery quickly and improve functional recovery, lower incidence of postoperative nausea and vomiting and so on. study confirmed a wide range of propofol in the central inhibition produced at the same time, also has reduced brain oxygen consumption, reduce intracranial pressure (ICP) and anticonvulsant, anti-inflammatory, antioxidant and bronchodilator properties. Therefore, the current propofol has been used in orthopedic surgery in the treatment of severe diseases. Here, let us look at some of propofol pharmacodynamic properties. I. Pharmacodynamic properties of propofol (A) anti-inflammatory properties of propofol Proinflammatory cytokines (proinflammatory cytokine) is pro-inflammatory cytokines, including tumor necrosis factor-@ (TNF-@), interleukin -1 (IL-1), IL - 6, IL-8, are mainly mediated guide the immune and inflammatory responses, so that the body of the trauma, stress throughout the body adaptive response, which triggers the cascade of cytokines can amplify the inflammatory response and host defense responses as an integral part. infection, surgical trauma, stress factors such as proinflammatory cytokine production and release of excessive destruction of the pro-inflammatory and anti-inflammatory cytokine balance, may lead to systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS) and other serious complications. Immune function of neutrophils is reflected in one hand, it is an important effect of the body cells to resist infection, mainly through chemotaxis, adhesion, phagocytosis, intracellular killing and so on to kill invading microbes and protec