Qi Decoction for a mechanism of unstable angina pectoris.doc

 PAGE \* MERGEFORMAT 14 Qi Decoction for a mechanism of unstable angina pectoris 【Abstract】 Objective To investigate the Qi Decoction for treatment of unstable angina pectoris in rats. Methods 41 patients were randomly divided into two groups. Control group, 20 patients given conventional treatment coronary heart disease; treatment group 21 cases in the control group based on the Canadian Qi Decoction. Observed before and after treatment of serum nitric oxide (NO), endothelin (ET), plasma fibrinogen (FG), von Willebrand factor (vWF), plasma tissue-type plasminogen activator (t-PA ), plasminogen activator inhibitor (PAI-I) changes. Results of clinical efficacy of the treatment group than the control group (P lt;0.05). In reducing NO, ET, FG, vWF, PAI-I, increase in t-PA than in the control group was significantly (P lt;0.05 ~ 0.01). Conclusion Qi Decoction be effective in prevention and treatment of unstable angina pectoris; the mechanism of thrombosis may be related to the pre-state (PTS) coagulation and fibrinolysis system in some sensitive molecular markers related to the impact. Keywords: unstable angina pectoris before the thrombosis of Qi-deficiency blood stasis syndrome state of Qi Decoction Unstable angina (UA) is the range of stable angina (SA) and acute myocardial infarction (AMI) between the clinical status of myocardial ischemia. In recent years, studies have shown that, UA is due to coronary plaque instability, secondary to thrombosis [1]. A large number of basic and clinical studies have shown that thrombosis in the vascular endothelial cells, coagulation, anticoagulation and fibrinolytic systems, and a variety of changes in blood rheology combined effect occurred. Thus, for the thrombosis prevention and treatment before the intervention on the UA and study of atherosclerotic plaque rupture mechanism and to find effective treatment for stable plaque measures have been more and more attention. This study explored the Qi Decoctio