Quercetin antitumor effects of zinc and the HepG22 mechanism of induction of apoptosis.docVIP

 PAGE \* MERGEFORMAT 11 Quercetin antitumor effects of zinc and the HepG22 mechanism of induction of apoptosis [Abstract] [Objective] quercetin zinc complex in vivo anti-tumor effect and mechanism. [Method] tetrazolium salt (MTT quercetin zinc complex was observed in human HepG2 hepatoma cells inhibition rate and by flow cytometry (FCM cell cycle observation and analysis, through the establishment of tumor-bearing mice models were quercetin and zinc complex of S180 tumor-bearing mice H22 tumor weight and survival time of mice was observed in vivo anti-tumor effect. [results] zinc complexes of quercetin can inhibit the proliferation of HepG2 in vitro, and inhibition was concentration dependent and could G0/G1 phase cells increased, S phase and G2 / M phase cells decreased. on the S180 tumor growth in mice significantly inhibited the survival time of mice with H22 significantly extend the role. [Conclusion] quercetin zinc complex in vivo can effectively inhibit tumor cell proliferation and induced HepG2 apoptosis of tumor cells. [Keywords:] quercetin, zinc, metal complexes, anti-tumor effect, apoptosis, HepG22 Abstract: [Objective] To study the antitumor functions and tumor cell apoptosis induced by Quercetin Zn. [Methods] MTT assay was applied to study the antitumor activities of quercetin Zn in HepG2 cell lines in vitro, and apoptotic cell was analyzed by flow cytometry. The in vivo antitumor action was studied by observing the variation of tumor weight and survival time of S180 and H22 mice. [Results] Quercetin Zn can inhibit HepG2 cells from growth and proliferation, and evoke apoptosis.Flow cytometry showed that it caused an increase at G0/G1 phase and a decrease at G2 / M phase and arrest at G0/G1 phase in the cell cycle.It also can inhibit the growth of cancer cells of S180 mice and prolong the survival time of H22mice. [Conclusion] Quercetin Zn has antiproliferative and proapoptotic effect on tumor cells in vivo and in vitro. Keywords:: Querce