RA synovial tissue collected in the mechanism of T lymphocyte.doc

 PAGE \* MERGEFORMAT 19 RA synovial tissue collected in the mechanism of T lymphocyte Abstract: Rheumatoid arthritis (RA) synovial tissue in a large number of infiltrating T cells in the synovial lesions in the initial and maintenance has an extremely important role, but the synovial tissue T-cells from the blood circulation across the vessel wall into the lesions. Pathological synovial tissue by generating a large number of inflammatory cells and release of chemotactic cytokines by peripheral blood T lymphocytes with the surface of the corresponding receptors, and thus select the desired self-reactive T cells into the synovial tissue lesions . In this paper, the mechanism described. Keywords: Rheumatoid arthritis; T lymphocytes; cell placement. ABSTRACT: Lots of T l cells infiltrate into the inflamed synovium and play an important role in the starting and sustaining pathological changes. But the T cell must migrate into the synovium from the peripheral blood, so the mechannism of which is very critical. Here we summarize the process of T cell recruited into the synovium, according to the recent studies. KEY WORDS: rheumatoid arthritis; T lymphocites; recruitment; Rheumatoid arthritis (RA) is a joint and articular cartilage injury is characterized by a chronic autoimmune disease. The basic pathological changes of synovitis, in a large number of inflammatory cells in the lesion formation of ectopic lymphoid microstructures, such as germinal centers, including a variety of inflammatory cells and inflammatory cytokines produced by local lesion constitutes a micro-environment, In this micro-environment, a variety of factors interact, so as to maintain the basic pathological changes. One as a major component of the cells, T cells in the lesions in a large number of infiltration, however, in RA pathophysiological role in the process once been questioned, [1] due to a large number of inflammatory cytokines in the synovium of non-derived T cells; However, with t