Rat gastric mucosa during healing of experimental gastric ulcer associated with apoptosis factor Bax Bcl2 expression changes.docVIP

 PAGE \* MERGEFORMAT 13 Rat gastric mucosa during healing of experimental gastric ulcer associated with apoptosis factor Bax Bcl2 expression changes Of: Zhang Jing Chen Liwei Lu Yang Wu Jingfang [Abstract] Objective: To investigate the healing of experimental gastric ulcer in rats during the pro-apoptotic protein Bax and anti-apoptotic protein Bcl 2 expression in gastric mucosa changes. Methods: The stomach anterior wall of the preparation of submucosal injection of acetic acid gastric ulcer model, immunohistochemistry detected the normal group, the ulcer group, saline group rat gastric mucosa the expression of Bax and Bcl 2, and image analysis system software for integrated optical density (IOD). Results: Bax-positive cells 1d gastric ulcers that increased expression of intensity, was significantly higher than the normal group and the corresponding saline group (P lt;0.01); after extended over time after surgery, the positive cells gradually decreased expression of fade to after 23d, ulcer group Bax IOD compared with the control group no significant difference (Pgt; 0.05). Bcl 2 positive cells in patients with prolonged expression gradually increased after injury to the gastric ulcer on day 6 the largest number of Bcl 2 positive cells, expression of the strong, and gastric ulcer after injury and 14d Bcl 2 IOD 10d ulcer after slightly less than 6d, but still remained at a high level, to gastric injury 23d, Bcl 2 IOD was significantly reduced, with the normal group, saline group showed no statistically significant (Pgt; 0.05). Conclusion: During gastric ulcer healing in Bax and Bcl 2 common repair the damage of the gastric mucosa. In early gastric injury to the main pro-apoptotic factors, anti-apoptotic factors on ulcer gastric mucosal protection and repair after injury primarily in the 6 ~ 14d. [Keywords:] gastric ulcer; Bcl 2; Bax; immunohistochemistry; rat [ABSTRACT] Objective: To investigate the expression of Bax and Bcl 2 proteins in gastric muc