Rat model of Parkinsons disease basolateral nucleus of amygdala neuronal activity of.docVIP

 PAGE \* MERGEFORMAT 16 Rat model of Parkinson’s disease basolateral nucleus of amygdala neuronal activity of Of: Wu Zhongheng, Zhang Qiaojun, Mrs, Xiang Li, Tao [Abstract] Objective To observe the unilateral destruction of the nigrostriatal pathway after the basolateral nucleus of amygdala (basolateral nucleus of amygdala, BLA) projection of changes in neuronal activity. Methods of 6 - OHDA lesions of substantia nigra pars compacta unilateral establishment Parkinson’s disease (Parkinson s disease, PD) rat model. extracellular glass microelectrode recording method, BLA projection neurons recorded electrical activity. Results In the control group and PD group BLA projection neurons in the frequencies are (0.66 + -0.13) Hz (0.08-2.73 Hz, n = 25) and (0.46 + -0.1) Hz (0.08-2.34 Hz, n = 24), PD rats than in normal group decreased firing rate, but no statistically significant difference (Pgt; 0.05). 96% of the control rats BLA projection neurons fired in bursts, irregular discharge of 4%, PD 90% of rats projection neurons show bursts, 10% irregular discharge. PD group BLA projection neurons in the form and the control group showed no significant difference (Pgt; 0.05). Conclusion Parkinson’s disease in rats BLA projection neurons in the frequency and firing pattern did not change. [Keywords:] Parkinson’s disease 6 - hydroxydopamine nuclear physiology of basolateral amygdala ABSTRACT: Objective To investigate the changes in neuronal activity of projection neuron in the basolateral nucleus of amygdale (BLA) after the unilateral lesion of the nigrostriatal pathway. Methods The rat model of Parkinson’s disease (PD) was established by 6-hydroxydopamine lesion of the substantia nigra pars compacta, and then the spontaneous discharge of projection neuron of the BLA was examined with extracelluar recording methods in control and PD rats. Results The results showed that the firing rates of projection neurons of the BLA were (0.66 + -0.13) Hz (0.08-2.73 Hz; n = 2