Rat spinal tumor model growing.docVIP

 PAGE \* MERGEFORMAT 13 Rat spinal tumor model growing [Abstract] Objective To block planting Preparation of tumor animal model of spinal tumors. Methods SHZ-88 rat breast cancer cell line inoculated female SD rat, into the tumor to the thymus SD rats after the implantation of lumbar transformed into tumors implanted in rat spinal animal model. Results 15 d after tumor implantation block pathological vertebral segment gross specimen see significant uplift the surface of the soft tissue mass formation, parcel part of the vertebral body surface; sagittal plane see the vertebral bone depression, in order to tumor tissue was fish-like, tumor Organization of the surrounding bone infiltration; Histology confirmed the tumor formation. Model composed of tumor rate of 80%. Conclusion tumor block planting method can be build in rat model of spinal tumors grow. [Keywords:] spinal disease; spinal tumor; Disease models, animal ABSTRACT: Objective To establish a spinal tumor model with the tumor segment plant method. Methods SHZ-88 mammary cancer cell of the rat was a subcutaneous injected into female newborn rat to produce subcutaneous lump. Then tumor segments were planted into the lumbar vertebral of the female thymectomizes rats, to establish rat spinal tumor model. Results The involved vertebral bodies was observed encapsulate parts of the vertebral body, at 15 days after the surgery. Bone defect can be seen in the sagittal plane, tumor tissue appears gray-white in color and infiltration into the vertebral body. The model of spinal tumor was established in 80% rats. Conclusion Spinal tumor model in rat simulated the malignant tumor character, which has great signification in the study the character of the metastasis spinal neoplasms, and comparisons of the curative effects of different therapies. KEY WORDS: spinal disease; spinal neoplasms; disease models, animal A good animal model of tumor to have the following features: similarity, repeatability, reliability,