Rational use of antihypertensive drugs.docVIP

 PAGE \* MERGEFORMAT 5 Rational use of antihypertensive drugs Since 1997, the U.S. JNC VI, 1999 Nian WHO-ISH hypertension treatment guidelines and China’s announcement, but also the progressive completion of several clinical trials and drug comparative study of how the different situations for the hypertensive patients the choice of antihypertensive drugs, hypertension risk factors of a comprehensive intervention strict control of blood pressure, the effective protection of target organs, understanding of these issues has reached a new height, it is necessary to sum up, in order to facilitate rational use in clinical practice and anti-hypertension drugs. 1, risk factors assessment and intervention The new guide highlights the risk factors of blood pressure levels and the coexistence of equal importance. Blood pressure level and cardiovascular disease was related to continuity, even in the context of normal blood pressure, blood pressure, the lowest incidence of cardiovascular diseases is also the lowest. Hypertension is not only hemodynamic disorders, but also metabolic disorders, Framingham Heart Study found that more than 80% of hypertensive patients complicated with one or more risk factors, their cardiovascular disease morbidity and mortality are directly related not only with blood pressure levels , but also on the associated risk factors and co-existence of other clinical illness. Prognostic risk factors include age, male sex, smoking, family history of early-onset cardiovascular disease, lipid disorders, overweight and obesity, impaired glucose tolerance, diabetes, microalbuminuria, blood fibrinogen levels and resting way of life, with diabetes or other cardio-cerebral vascular diseases. Recent studies have suggested that heart rate increased fast, high uric acid, high hyperhomocysteinemia, which may be an independent risk factor for cardiovascular disease. Many research suggests that is closely related to heart rate and blood press