Recent bronchial asthma drug therapy.doc

 PAGE \* MERGEFORMAT 10 Recent bronchial asthma drug therapy Bronchial Asthma is a manifestation of repeated episodes of wheezing, difficulty breathing, chest tightness, cough, and often appears extensive and varied reversible airflow limitation, most patients can be treated on their own to mitigate or alleviate the common diseases characterized by, in recent years, its incidence rate and mortality rate are the upward trend. According to the definition of bronchial asthma by eosinophil cells, mast cells and T lymphocytes and other inflammatory cells involved in chronic inflammation of the trachea. Induced by a variety of factors, some of the mechanism is not clear, so the therapeutic effect of various drugs in different sectors, this paper recent developments on the medical treatment of bronchial asthma are summarized below. 1, theophylline class Theophylline is commonly used anti-asthmatic drugs, the application has been for over 50 years. Theophylline belongs to yellow fat derivatives in recent years, many studies have shown that, in addition to the direct smooth muscle relaxation, but also has anti-inflammatory effects, specifically manifested as follows: First, suppress IgE-mediated mast cell release of histamine, by increasing the body addicted Acid granulocytes and mast cell cyclic adenosine monophosphate (cAMP) concentration and inhibit its release; Secondly, can reduce the respiratory tract in bronchial asthma need who interleukin 4 (IL-4) and interleukin-5 (IL-5) to influence the content of arachidonic acid metabolism, so that eosinophils release of leukotriene reduced by about 61%; third, theophylline could inhibit neutrophil adhesion capillary wall, and further inhibit their travel out of the capillary blood vessels play a role in phagocytosis, while able to enhance monocyte - macrophage chemotactic effect, due to asthma results are obvious, is one of the clinical drug of choice, currently used are aminophylline, gasping for breath, cough tablets