Recombinant human erythropoietin on rabbit retinal ischemia-reperfusion injury protection structure.docVIP

 PAGE \* MERGEFORMAT 16 Recombinant human erythropoietin on rabbit retinal ischemia-reperfusion injury protection structure Of: Wang JM, Song Yanping, Sun is a science, Pinghai Xiao, Hui Na, Fanya Zhi, Hu Kai [Abstract] Objective To investigate the subcutaneous injection of recombinant human erythropoietin (recombinant human erythropoietin, rhEPO) on ischemia-reperfusion injury in rabbit retinal structure in rats. Methods 24 healthy rabbits Choose a cause of retinal ischemia reperfusion injury model (model group, a total of 24 eyes), fellow eyes without any treatment as the control group (24 eyes). Another 24 healthy rabbits Choose a modeling (EPO group, 24 eyes) at 3 days before modeling and modeling the end of each rabbit subcutaneous rhEPO 100IU/kg 1 time. at 1,3,7,14 days after modeling, respectively, removal of 6 rabbits in each group to observe the retina organizational structure and morphology, measurement of the inner retina (inner retina layer, IRL) thickness and counting of retinal ganglion cells (retinal ganglion cell, RGC). Results from the first 3 days after modeling, the beginning, the model group than in the control group, reduce the number of RGC, IRL thickness thinner (P lt;0.05, P lt;0.01). Since modeling the first 3 days after the EPO group than in model group IRL thickness (P lt;0.05, P lt;0.01), self-made 7 days after modeling EPO group compared with the number of RGC multi-model group (P lt;0.05). Conclusion rhEPO can significantly improve the ischemia-reperfusion injury in rabbit retina structure, could be a nerve ischemia-reperfusion injury agent. [Keywords:] Recombinant Erythropoietin neuroprotection of retinal ischemia and reperfusion in rabbits ABSTRACT: Objective To investigate the neuroprotection of recombinant human erythropoietin (rhEPO) from retinal ischemia and reperfusion injury in rabbits. Methods Retinal ischemia and reperfusion injury models were made in one lateral eyes of 48 rabbits (24 in model group and 24 in