Research progress of leukoaraiosis.docVIP

 PAGE \* MERGEFORMAT 13 Research progress of leukoaraiosis [Keywords:] Progress leukoaraiosis Leukoaraiosis (leukoaraiosis, LA) by the Canadian neurologist made in 1987, Hachinski and other imaging diagnosis of a term used to describe the periventricular white matter and semi-oval center of patchy or spotty changes. CT manifestations low density lesions, MRI showed T1WI was so low signal, T2WI high signal. With the wide application of CT and MRI, LA more and more in the middle and elderly patients were found [1]. The main pathological changes extensive white matter demyelination, and arcuate fibers retained. LA in recent years about the clinical, imaging, pathology, pathogenesis of such widespread attention. is almost a few years on the research summarized below leukoaraiosis. 1 Leukoaraiosis the etiology, pathogenesis and pathological changes 1.1 The cause of leukoaraiosis all causes demyelination, edema, ischemia, hypoxia, and micro-infarction, can cause abnormal changes in white matter. Extensive hypoperfusion of cerebral blood flow and cerebral atherosclerosis is the formation of the main pathological LA mechanism [2]. LA is closely related to atherosclerosis and hypertension. age and LA’s most closely related, almost all studies that age is the only independent risk factors of LA. Liguo Yan et al [3] found that elderly patients with stroke risk factors Shi Miqie history and hypertension associated with diabetes also have significant relationships. the young group of smoking, alcohol consumption rates compared with the old group was significantly different, some young LA is caused by a number of specific causes, such as encephalitis history delayed encephalopathy after carbon monoxide poisoning. the young group the level of LA in patients with serum total cholesterol and apolipoprotein B levels were significantly higher than the normal control group. Some scholars study, carotid atherosclerosis was significantly associated with leukoaraiosis, ca