Research Status of gene therapy vector.docVIP

 PAGE \* MERGEFORMAT 13 Research Status of gene therapy vector [Keywords:] gene; therapy; vector Gene therapy is a new treatment, can be used for the treatment of many diseases, including cancer, genetic diseases, infectious diseases, cardiovascular diseases and autoimmune diseases. Gene therapy is usually refers to the genetic material (DNA or RNA) introduced into the patient’s cells in order to achieve the purpose of the method of treatment of disease [1 ~ 3]. It is accompanied by DNA recombinant technology to mature and developed a new type of molecular treatment, is currently in the development of bio-medicine a major breakthrough in .1968, the United States Michael Blaehser for the first time scientists have made in the medical profession the concept of gene therapy .1990 year Anderson and other American scientists had a real sense of the first gene therapy clinical trials, won the preliminary success [ 4]. In the course of gene therapy, gene delivery system is the most critical technology. At present, gene transfer vectors have emerged two main aspects, namely, viral gene delivery systems and non-viral gene delivery systems. In this paper, application of the principle of gene therapy vector, status of species and studies are reviewed. A viral vector Foreign gene into the cells often need transportation, while the virus is a natural evolution in the long survive without cell structure of the smallest and most simple parasitic life forms. The virus can often be an efficient access to specific cells, expression of self - protein, to generate new virus particles was, therefore, became the first of the modified virus gene therapy vectors. viral vectors in gene therapy application of a wide range, about 70% of treatment programs using viral vectors [5,6]. viral vectors, including anti - retroviral vectors, adenovirus vector, adeno-associated virus vectors and herpes simplex virus vector and so on. 1.1 retroviral vector retrovirus belonging to positive-stra