Rheumatoid arthritis synovial cell apoptosis and related gene expression of Fas.docVIP

 PAGE \* MERGEFORMAT 5 Rheumatoid arthritis synovial cell apoptosis and related gene expression of Fas [Abstract] Objective: To study patients with rheumatoid arthritis (Rheumatoid Arthritis, RA) patients with synovial tissue cell apoptosis and related gene expression and significance of Fas. Methods: Immunohistochemical methods, 9 patients and 8 normal controls apoptosis in synovial tissue cells and the expression of Fas were detected. Results: RA patients with synovial tissue cell apoptosis was significantly lower than the control group, while the percentage of Fas positive cells was significantly higher. Conclusion: RA synovial tissue in patients with reduction in apoptosis may lead to excessive proliferation of synovial membrane and thus one of the reasons the loss of joint function, Fas expression increased while but you can not directly induce cell apoptosis. [Keywords:] rheumatoid arthritis; apoptosis; immunohistochemistry Rheumatoid arthritis (RA) is a common sexually transmitted diseases, chronic inflammation of joint tissue in order to become the main performance of systemic disease, China’s incidence rate among adults is about 0.3%. The main pathological features of RA is synovial proliferation and invasion of cartilage and bone tissue damage, have a high morbidity, its pathogenesis is not yet very clear. In recent years, studies have shown that apoptosis is an important part of their mechanism of pathogenesis [1 ~ 3]. We use TUNEL method and immunohistochemical staining of formalin-fixed and paraffin-embedded RA synovial tissue of patients and controls, cell apoptosis and Fas gene expression studies to investigate the mechanism of RA synovial proliferation and apoptosis -related genes Fas-mediated apoptosis in the pathogenesis of RA. 1 Data and methods 1.1 The clinical data of Xi’an, at the fifth hospital, 9 cases of surgical treatment of RA patients are in line with the 1987 American College of Rheumatology diagnostic criteria for RA,