Ribose in the protection of heart function in the role of the.doc

 PAGE \* MERGEFORMAT 16 Ribose in the protection of heart function in the role of the Keywords: ribose pentose phosphate pathway of cardiac function Abstract pentose phosphate pathway in the heart of the development of all the animals are not good. Re-perfusion after myocardial ischemia, its myocardial ATP levels to go through several days to recover to normal levels. This paper summarizes the ribose myocardial perfusion solution can significantly improve the recovery rate of ATP to promote ATP synthesis, improve cardiac function. The article also on the clinical application of ribose elaborated. Effect of Ribose on Protecting Global Heart Function D-Ribose (D-Ribose) is the natural existence of a five-carbon aldehyde sugar, in 1909 first to Levin (Levene) and Jacobs (Jacobs) identified. After the adoption of the fifties with glucose as raw material of organic synthesis or by nucleotide hydrolysis production and eighties began fermentation production abroad. Now, fermentation has reached a very high level, for the future to explore new uses for creating the conditions for the ribosome [1,2]. Before D-ribose is mainly used for synthesis of vitamin B2, raw materials, in recent years, also reported that can be used for synthesis of anti-virus, anti-tumor nucleoside drugs. In addition, it in itself can also be used to treat ischemic heart to improve cardiac ischemic tolerance capacity to improve the overall function of the heart; treatment of exercise-induced muscle soreness, adenosine deaminase deficiencies caused stiffness, as well as the lack of intracellular phosphorylase caused by muscle pain, etc. [3]. The following introduces the ribose in the protection of heart function in the role. Pentose phosphate pathway of a physiological function of Pentose phosphate pathway is the sugar, fatty acids, purine nucleotides and pyrimidine nucleotide metabolism in the hub. From glycogen breakdown or cellular uptake of glucose produced by glucose -6 - phosphate (G-6