Schizophrenia and 5.docVIP

Schizophrenia and 5 Author: Shi Hong Lu in the route of Wang Shuang [Keywords:] schizophrenia; 5 [Keywords:] Schizophrenia; 5-HT system; gene polymorphism; receptor; Biology In this paper, 5-HT (5HT) the biological characteristics, receptor pharmacology genetics, transporter proteins and metabolic enzymes in recent years, molecular genetics of schizophrenia research in related fields. With the molecular cloning, radioactive ligand method and FMRI technology in the spirit of the modern pharmacological research, particularly in the past 10 years to discover a new class of belonging to 5HT2/D2 antagonists (SDAs) of the atypical antipsychotics (eg, chlordiazepoxide ping, etc.) become first-line drug treatment of schizophrenia. From the two systems are known receptors, transporters and metabolic enzyme genes for schizophrenia and be associated with functional polymorphism analysis (candidate gene approach) is currently the best one of the means. 1 5HT system, the biological activity and receptor classification, distribution, function 5HT receptor subtypes have as many as 14 species, in addition to 5HT3 is a ligand-gated ion channels, most of them belong to G protein-coupled receptor with seven transmembrane structure of the 5HT receptors. 1.1 5HT1 receptor 5HT1A receptors mainly in the frontal cortex, dorsal raphe nuclei, hippocampus, amygdala, spinal cord and other brain regions in the forebrain; 5HT1B receptors mainly in the striatum, quality, basal ganglia, hypothalamus, pituitary, New cortex and smooth muscle; 5HT1C receptors are mainly distributed in the ventricles of the choroid plexus, thalamus under the nucleus, substantia nigra, raphe nucleus, reticular nucleus and locus coeruleus and other brain regions. Lysergic acid diethylamide (LSD) and 5HT1C receptors have a high affinity combination can make a person a sense of hallucination and perceptual barriers, 5HT1E receptor distribution and 5HT1D similar, but it is dispersed in the cerebral cortex, with a