Sciatic nerve injury model and the branching selective NMDAR CGRP and pain of the relationship between.docVIP

 PAGE \* MERGEFORMAT 10 Sciatic nerve injury model and the branching selective NMDAR CGRP and pain of the relationship between Chronic pain is a common disease of adults in all of its prevalence in the 2-40% range [1], which is by the feeling of injury and neuropathic pain of two parts [2]. Although no specific statistics in our country, but in the United States in patients with chronic neuropathic pain is estimated that there are three more than 10 million, including the following conditions: cancer-related pain, spinal cord injury, low back pain, pain and hallucinations [3]. Repeated and persistent pain (neuralgia from back pain to the surface) accounted for the U.S. Health Association, 45% [4,5], treatment of pain in the UK 25% of patients have experienced symptoms of neuropathic pain and distress [6]. Neuropathic pain is chronic pain in the Miao Xu a more pathological symptoms. Neuropathic pain with a variety of peripheral nerve disorder associated with the performance of a group of common symptoms, including diabetes, hypothyroidism, uremia and other related neurological disorders. International Pain Society (IASP, 1994) such as peripheral or central nervous system dysfunction caused by direct injury of pain is called neuropathic pain. Neuropathic pain is a challenging field of medicine research project, at present the pathogenesis is unclear, yet the lack of effective treatment measures. On the pathogenesis of neuropathic pain, studies have mostly been derived from animal models; Although the model there are still many shortcomings, but it is to understand and explore the human pathogenesis of neuropathic pain provides a useful tool. Past uses include chronic constrictive injury model (CCI model) [7], part of the sciatic nerve ligation model (PSNL model) [8] and spinal nerve ligation model (SSNL model) [9], including a variety of animal models to simulate the neuropathic The clinical characteristics of pain, to study its mechanisms, its for the treatmen