人工合成抗菌药26594.pptVIP

synthetic ;Classification ;task;Fluoroquinolones ;Classification of quinolones;Fluoroquinolones ;Antibacterial spectrum;Mechanism of action;;Pharmacokinetics ;Resistance ;Mechanism of resistance;Clinical application;Adverse reaction;Contraindication ;Common fluoroquinolones in clinic;Ciprofloxacin The strongest antibacterial action in vitro Bioavailability is 38-60% Strong effect for G- bacilli and drug-resistance G+/G– Therapeutic application is mainly for infections of other drug resistance G- bacilli. No effect for most anaerobian. ;The same antibacterial character to ciprofloxacin In addition, ofloxacin has effect for mycobacterium tuberculosis,chlamydia trachomatis and some anaerobian. The second-line agent for treatment of tuberculosis Levofloxacin Its antibacterial activity is double of ofloxacin’s. ; good absorption by oral administration Its bioacailability is about 99%. Distributed widely in body fluids and tissues Strong antibacterial activity in vivo Adverse reaction is more. ;Sulfnamides ;Chemical constitution;classification;Antibacterial spectrum;Action of mechanism;Mechanism of action;Mechanism of resistance;Pharmacokinetics ;Adverse effect;Trimethoprim （TMP）;Action of mechanism;sulfadiazine（SD）;Sulfisoxazole(SIZ) and sulfamethoxazole(SMZ);SASP itself is no antibacterial activity. Resolving into sulfapyridine and 5-aminosalicylate in intestinal tract acute or chronic colitis gravis,Crohn’s disease,proctitis ulcerosa;SML infection burn Powerful inhibitory action to tetanus bacillus and Pseudomonas aeruginosa SD-Ag Antibacterial, astriction Raw surface infection of burn wounds SA-Na Therapy of ophthalmic infections including conjunctivitis and trachoma. ; nitrofurans;Nitromidazoles ;practice