奥沙利铂联合替加氟持续静脉注射治疗晚期胃癌临床观察.pdfVIP

肿瘤防渝研究200γ 偌瘸34 卷第 11 期 • 871 • ·临床应用· 奥沙利铅联合替加氟持续静脉注射治疗 晚期胃癌临床观察 胡定学，陈容拖，雷僻坤，张丽 Clinical Observation of Combined Chemotherapy with 伽aliplatin and Tegafur by Continu~ 008 Intraveno08 Drip for Treatment of Advanced Gastric Cancer HU Ding-xue.CHEN Rong-yan.LEI Yan-wei.ZHANG Li Medícalde阳rtment ,Kaifeng Tumor Hosρtíal •Kaifeng 475oo3 ,China Abstract:Objective To evaluate clinical efficacy and toxicity of chenωtherapy with Oxaliplatin (OXA) and Tegafur by continuous intravenous drip in treatment of advanced gastricωnce民 Methods A to组lof 21 patients were pathologically ∞nfinned as stage N gastric cancer missing opportunity of surgical opera- tion. OXA 130mg/nr wωinfused for two hours on dl ,and Tegafur 600mg/m2 wasωntinuous infused by pump on dl to d5.臼le cycle ∞mprised 3-4 weeks，缸td the efficacy was evaluated after 2 cycles and 4 weeks.R筒且Its In 21 patients ,CR was seen in 0 patients and PR in 12 patients(57. t%)and NC in 6 pa唰 tients(28. 6%)and PD in 3 patients (14. 3%) .with ωtal response rate of 57. 1%. The m时ian r，阳市sion period was 4. 6 months. the median survival period was 8.3 months. The CBR was 85.7%. The toxicity was mild neural toxicity and gastrointestinal tractωxicity. Cooclusion OXA combined with Tegafur by pur叩 for treatment of advanced gastric cancer has relatively high res阳nse rate. and the toxicity can be well tolerated. Keywl舰也:OXA ,T egafur; Chemotherapy; Gωtric cancer 摘 要:目的 观察奥沙利销与替加氟持续静脉滴泣联合化疗治疗晚期胃癌的临床疗效。方法 21 例 均为不能手术的N期宵癌病人.均接受奥沙利钩 130mg/时，铮满 2h. 第 1~;替加氟ωOmg/时，经徽 :1署主持续 24h 静脉输入，第 1-5 天，3-4 周为一周期，连用 2 周期后.4 周伴价疗效.结果 21 例患者 中，CRO 例，PR 12 例。7.1%).NC61如~ (28.6%) ,PD 3 例(14.3%) ，总有效率57.1%. 中位缓解期4.6 个月，中位生存期8.3个月，临床受益率85.7%. .:j鲁创JJ..Á.是.i:A岛是神经毒性、忍心、呕吆和腹泻等。篇论 奥沙利销与替加氟持续静脉滴球联合化疗治疗晚期胃癌可获得较高疗效，毒制反应能耐受，可作为晚 期胃癌的有效治疗方案，值得进一步研究. 关键词:J电沙和l 伪$替加氟p 化疗;l可癌 中图分类号:R735.2