Supercritical carbon dioxide extraction process on extraction rate of osthol Research.docVIP

 PAGE \* MERGEFORMAT 21 Supercritical carbon dioxide extraction process on extraction rate of osthol Research Author: Gong Zhu-yun, ZHANG Gao-Yong Nie Yongliang, GU Hui-Xian Keywords: supercritical carbon dioxide extraction;,, Osthol;, extraction rate;,, coherent design of quadratic regression Abstract: The purpose of the five factors, the interaction between an inspection to determine the optimal supercritical CO2 extraction process parameters. Methods The design of quadratic regression coherent approach. The results of P extracted with the interaction between the T sub-Ⅰ more obvious, T sub-sub-Ⅱ Ⅰ and T followed by the interaction between the, T Cui and T sub-Ⅰ, T extracted with the P sub-Ⅰ, P and T sub-sub-Ⅰ Ⅱ interaction between the extraction rate of Osthol have a certain influence. Optimized process conditions were: extraction pressure 40 MPa, extraction temperature 40 ℃; separation Ⅰ temperature of 45 ℃; separation Ⅱ pressure 5 MPa, separation Ⅱ temperature of 46 ℃; CO2 flow of 18 L / h, extraction time 80 min In these conditions, the extraction rate of up to Osthol 4.32%. Conclusion quadratic regression coherent design can objectively reflect the objective function of various factors on the impact of the law. Keywords:: supercritical carbon dioxide extraction; Osthol; extraction rate; quadratic regression continuity of design Cnidium Cnidium Department of Umbelliferae species Cnidium Cnidium monnieri (L.) Cuss.’s Dry ripe fruit. The chemical composition of traditional Chinese medicine Cnidium monnieri more complex, in addition to volatile oil, the major coumarin for Cnidium Total (Total coumarins of Fructus Cnidii, TCFC). TCFC mainly osthol (osthol) and the European Imperatorin (inperatorin)-based, currently known chemical constituents of Cnidium monnieri extract up to more than 40 kinds. Osthol taste hard, warm in nature, with cold-dispelling, Qufeng, pesticides and other functions. Wet Bi for low back pain, Yin itching va