Suppressing hepatic-fibrosis and demolition parties on liver fibrosis in rat liver tissue of TGF-β 1 PAI-1 protein expression.docVIP

 PAGE \* MERGEFORMAT 14 Suppressing hepatic-fibrosis and demolition parties on liver fibrosis in rat liver tissue of TGF-β 1 PAI-1 protein expression Author: Chen Jun Hong-Guo Wang Jimeng to make the right to have [Abstract] Objective To investigate the inhibition of liver fiber and demolition parties on liver fibrosis in rat liver tissue of TGF-β 1, PAI-1 protein expression. Methods of carbon tetrachloride (CCl4) Act rat liver fibrosis model was observed by immunohistochemical staining and demolition parties suppressing hepatic-fibrosis of liver fibrosis model in rat liver tissue TGF-β 1, PAI-1 expression. The results of each group animals, after treatment, liver tissue TGF-β 1, PAI-1 protein expression in different degrees of reduced volume, in which all parties suppressing hepatic-fibrosis group than in the other treatment group significantly decreased. Conclusion Chinese herbal compound suppressing hepatic-fibrosis and demolition may effectively prevent liver fibrosis, especially in suppressing the role of liver-fiber whole recipe the best, and its mechanism may be through inhibiting liver fibrosis TGF-β 1, PAI-1 protein expression achieved. [Keywords:] liver fibrosis treatment method TGF-β 1 PAI-1 immunohistochemistry Abstract: Objective To investigate the influence of Yiganxian decoction and its separated decoction on the expression of TGF-β 1 and PAI-1 protein in liver tissue of hepatic fibrosis in rats. MethodsLiver fibrosis model rats were induced by carbon tetrachloride, the expression and localization of TGF-β 1 and PAI-1 in liver tissue were analysed by the method of immunohistochemistry. ResultsAfter treatment with medication, the positive expression of TGF-β 1 and PAI-1 protein in liver tissue was decreased at different levels. Yiganxian decoction was better than other groups.ConclusionYiganxian decoction and its separated decoction can effectively prevent and treat the liver fibrosis in rat model. Yiganxian decoction is the most effective. It