Super-antigen - anti-tumor effect of staphylococcal enterotoxin Research Progress.docVIP

 PAGE \* MERGEFORMAT 18 Super-antigen - anti-tumor effect of staphylococcal enterotoxin Research Progress Keywords: superantigen; staphylococcal enterotoxin; malignant tumor; biological treatment Super-antigen (superantigen, SAg) is Janice White, etc. [1] in 1989 studied the Staphylococcus aureus enterotoxin (Staphylococcal enterotoxin, SE) on T lymphocytes have a strong stimulating effect made after the new concept of immunology. Since then, the gradual deepening of the people in the research, and have made great progress. Application of SAg for anti-cancer treatment is the age of 90 until the 20th century, the emergence of a new treatment. SAg is a large group, including many bacteria, viruses, and animals within the body’s own product, and the present can be reported for clinical anti-tumor effect of SAg only SE, while SE is the strongest known stimulant of human lymphocyte and the most powerful cytokine inducer. Is the first one was found to super-antigen, is also the most current research and clinical use of the most widely SAg. SE mainly include Staphylococcus aureus enterotoxin A (SEA), Staphylococcus aureus enterotoxin B (SEB), Staphylococcal enterotoxin C (SEC). With the new bio-technology applications built with its inherent biological properties, its clinical application prospects will be broader. In this connection, I now make the following overview. 1 SE of the anti-tumor mechanisms 1.1 SE-dependent cell-mediated cytotoxicity T cell antigen recognition, under normal circumstances, foreign antigens by antigen-presenting cells required (antigen-presenting cell, APC) intracellular processing and MHC Ⅱ class I molecules with the combination of co-expression on the cell surface, and T-cell receptor (T Cell receptor, TCR) α-and β-strand-specific binding, can activate T cells. The SAg as a special class of antigen molecules, and common antigens there is a qualitative difference in [2], they do not need intracellular antigen p