The biological mechanism of tumor hyperthermia.docVIP

 PAGE \* MERGEFORMAT 27 The biological mechanism of tumor hyperthermia [Abstract] hyperthermia as a treatment for cancer is an important means there is a growing cause for concern, this article hyperthermia to the biological mechanisms involved in tumor blood vessels, such as blood supply, ph value, tumor cell morphology, cell wither death, cell cycle, immune, and HSP, P53, Bcl-2 molecule and so on to make a brief overview of the changes. [Keywords:] hyperthermia; apoptosis; immunity; HSP Busch since 1866, was first reported by a German doctor one cases of pathologically confirmed sarcoma of the face, because 2 times high fever infection erysipelas, the tumor disappeared since the survival of patients, the frequent reports of hyperthermia treatment of cancer, especially in the past 20 years, as the basis for in-depth study, this ancient therapy hyperthermia achieved rapid development and now hyperthermia in clinical practice has been more widely used, and showing good efficacy [1,2], it is the biological mechanism of hyperthermia has also been more in-depth understanding. This paper, to make a review. Hyperthermia on tumor cells in a direct killing effect of 1.1 The cell membrane and cytoskeleton damage The cell membrane is the target organ of hyperthermia, heat after the cell membrane fluidity and permeability increases, leading to changes in intracellular environment, as well as hampered the membrane transporter protein and cell surface receptor function and tumor cell membrane cholesterol levels lower than normal cells, , membrane fluidity strong, and therefore more sensitive to the hyperthermia. Hyperthermia can also lead to cytoskeletal damage, caused by intracellular Ca2 + concentration is reflected mainly in the cell morphology, mitotic apparatus, nucleus and nucleolus and other damage. 1.2 organelle dysfunction High fever, many organelle dysfunction, such as structural damage mitochondria, rough endoplasmic reticulum degranulation