The biological mechanisms of early pregnancy factor and its role.docVIP

 PAGE \* MERGEFORMAT 27 The biological mechanisms of early pregnancy factor and its role Of: repair Xiaona, Shiyuan Gang, Guan Wei Jun, Yue-Hui Ma [Keywords:] early pregnancy factor EPF (early pregnancy factor, EPF is present in maternal serum in early pregnancy, an immune inhibitory factor, is considered to be members of heat shock protein family chaperone protein 10 (Cpn10 homologues, play in the extracellular effects of immune suppression and the role of growth factors, subsequently found it on the wound healing process and some supportive of the growth of malignant tumors. rosette inhibition test available (RIT do biological identification. but because of its complexity RIT detection and low detection efficiency and other issues, EPF’s application has been extremely limited. In recent years, with the monoclonal antibody (McAb technology continues to progress, EPF test not only as a super-human and animal indicators of early pregnancy diagnosis, but also in predicting abortion and early embryonic death, effect of rapid identification and early evaluation of embryo transfer in the reproduction of male livestock have an important significance. and EPF for the prediction of early embryo development, pregnancy, maternal embryos to help understand the identification, detection of immune tolerance and fertilization mechanisms such as possible. We hope to EPF prepared specific McAb, for ultra early pregnancy diagnosis, and abortion and the early diagnosis of certain malignant tumors and prognosis. A source of early pregnancy factor A long time, the source and structure of the EPF did extensive research, that there is a factor in fertilized eggs after induced EPF.Lash [1] in different conditions such as in vitro: embryo culture medium (ECM, platelet activating factor (PAF and the release of cortical granules medium (CGRM under the stimulation of estrus ovaries and fallopian tubes of mice to see whether there is production of EPF and detected with RIT