The genetic mechanism of disc degeneration research.docVIP

 PAGE \* MERGEFORMAT 27 The genetic mechanism of disc degeneration research Keywords: intervertebral disc degeneration Intervertebral disc degeneration (intervertebral disc degeneration, IDD) is a series of spinal degenerative disease, the premise and basis for the occurrence of pathological processes in clinical practice usually manifested spinal stenosis, spinal segmental instability, low back pain, cervical spondylosis, disc, etc. disease. The traditional view that the IDD mainly related to the excessive load caused by physical damage and the aging process accompanying the change. With the continuous deepening of relevant studies, people’s awareness of IDD and its causes has been enormous progress. Several studies in recent years, especially for those with IDD twins study found that genetic factors may be the occurrence and development of IDD play an important role. In this paper, for a review of relevant studies. A family of disc degeneration IDD If there is familial, then there may be prompted to genetic factors. Battie et al 〔1〕 coverage of the 20 pairs of identical twins persons (aged 36 to 60 years) study found that: IDD study the extent and location were the only significant familial. In order to understand this is due to genetic factors, familial or cultural, customs to pass along, some scholars of the monozygotic twins and pairs of identical twins who were classified research. Sambrook et al 〔2〕 pairs of 86 pairs of monozygotic twins and 154 pairs of pairs of identical twins who carry out MRI scans of the spine revealed: genetic factors have a significant impact on IDD, and is greater than the impact of environmental factors on the IDD, especially in the lumbar spine . 2 and disc degeneration-related genes So far, IDD major application of genetic research is a kind of candidate gene analysis. Candidate genes are generally expressed in the diseased tissue abnormalities or known disease-related genes and th