The molecular mechanism of apoptosis.docVIP

 PAGE \* MERGEFORMAT 26 The molecular mechanism of apoptosis [Abstract] Objective To study the phenomenon of apoptosis molecular mechanism. Methods A literature review of the methods on the phenomenon of apoptosis occurred in the molecular mechanism are reviewed. The results affect the biological mechanisms of apoptosis is very complicated, there are a variety of factors, genes and proteins involved in cell apoptosis, such as nerve growth factor (NGF), heat shock protein (HSP) and bcl-2 family, and so on. Conclusions Apoptosis by a variety of biological factors influence and regulation. [Keywords:] apoptosis gene protein Cell apoptosis (cell apoptosis) is intended to use ancient Greek, said the cell as the autumn leaves litter the same way the death of the cell to follow its own procedures, its the end of their lives, finally cracking a number of apoptotic bodies were engulfed other cells. 1972, Kerr was first proposed by the concept. Apoptosis is a basic phenomenon of life is to maintain dynamic balance of the body cells of the basic measures. In the stage of embryonic development through apoptosis remove excess cells and having completed its mission to ensure the normal development of embryos; cell apoptosis in the adult stage of a clear cell aging and diseases to ensure the body’s health. Apoptosis is the process by precise gene regulation. Apoptosis involves a highly complex molecular mechanism of the apoptosis-related molecular mechanisms will now make a brief summary. 1 cell apoptosis pathway Apoptosis are mainly two ways, one is a cell-surface receptor-mediated apoptosis through extracellular signal-activated cell apoptosis within the enzyme Caspase-8, a release through the mitochondrial apoptosis-activating factor activate the enzyme Caspase-9 . Activation of Caspase-8 and Caspase-9 can be activated Caspase-3, will be an important intracellular protein degradation, causing cell apoptosis [1,2], shown in Figure 1. 1.1 the surface of apoptotic rec