Thrombin and tumor metastasis.docVIP

 PAGE \* MERGEFORMAT 28 Thrombin and tumor metastasis Authors: Meng Yuhong, Yu Ji-Yao, Lu Ying-lin Abstract Thrombin is a multifunctional serine protease, a series of in vivo physiological and pathological processes play an important role. It is not only involved in hemostasis and coagulation, inflammation, immune response, tissue repair and wound healing, but also activate the oncogenic potential of normal cells and lead to malignant cells, metastatic phenotype. Thrombin is a tumor cell mitogenic agents, tumor cells can enhance the proliferative response of cytokines to enhance adhesion of tumor cells to platelets and in vitro invasion of extracellular matrix, promoting tumor angiogenesis and tumor micro-environment of tissue reconstruction. Thrombin receptor family, PARs-mediated cell biological effects of thrombin. Thrombin on the growth of tumor cells with a bi-directional Regulation of low concentrations of those engaged in promoting growth, high concentrations inhibited the growth of those who, even lead to apoptosis of tumor cells. In this paper, the biological function of thrombin, thrombin and thrombin receptor and tumor, etc. were reviewed. 【Key Words】 thrombin neoplasms; tumor metastasis Thrombin and Tumor Metastasis - Review Abstract Thrombin is a multifunctional serine protease that plays a key role in a variety of physiological and pathological conditions. In addition to the role in hemostasis and coagulation, thrombin has other numerous biological activities affecting inflammation, immune responses, tissue repair and wound healing. Apart from its physiological role thrombin activates the oncogenic potential of both normal and malignant cells and leads a metastatic phenotype. It is a potent mitogen for many tumor cells. It potentiates the proliferative response of tumor cells to some growth factors, increases the adhesive properties to the platelets and invasion processes of tumor cells to the extracellular matrix,