Traumatology bone-chip fracture of the rabbit model of renal transforming growth factorβ 1 expression in.docVIP

 PAGE \* MERGEFORMAT 14 Traumatology bone-chip fracture of the rabbit model of renal transforming growth factorβ 1 expression in Author: Zhang Jiping Zhang Fen Geng Gong Li Hui Yao Qiu Jianwen Ai-Hua Lin Xu Bilian WU Tie [Abstract] [Objective] To observe the model Shangke bone chip fracture healing in rabbit renal transforming growth factor  β 1 (TGF  β 1) expression changes. [Method] selected 36 male New Zealand rabbits, are copied into a unilateral radial bone in the upper 1 / 3 standard fracture model; were randomly divided into model control group and Traumatology bone chip groups, each with 18, each further divided into three sub-groups, each sub-group 6. 2 days after the first dose starting at 11,21 and 35 days after operation, each sub-group of animals were sacrificed, take the kidney, using immunohistochemical staining were measured using image analysis of renal expression of TGF  β 1 content. [Results] 11 days and 21 day injured renal tissue Division bone chip TGF  β 1 expression level than those in model group significantly increased (P amp;lt;0.05 or P amp;lt;0.01); the first 35 days traumatology osteosynthesis film group and model control group no significant difference (Pamp;gt; 0.05). [Conclusion] Shangke bone pieces to promote the role of fracture healing may be related to regulating renal tissue TGF  β 1 expression. [Keywords:] Traumatology bone chip / pharmacology fracture / TCD kidney tissue / pathology disease model Animal Rabbit Traumatology bone chip is widely used in orthopedic clinical Chinese medicine, with blood circulation, reduces swelling, pain, added muscle bone, kidney Zhuanggu functions. Clinical and Experimental Research has histological, morphological, bio-mechanics angles confirm that the drug can promote the fracture healing [1-2]. Studies have shown that films can be adjusted Shangke bone fracture healing in rabbits callus of transforming growth factor  β (TGF  β 1) synthesis and secretion, and its role in