Treatment of corneal neovascularization Progress.docVIP

 PAGE \* MERGEFORMAT 32 Treatment of corneal neovascularization Progress 【Abstract】 variety of pathological factors can result in corneal neovascularization, neovascularization of the cornea often leads to severe visual impairment, corneal transplant surgery failed. In recent years, at home and abroad for the treatment of corneal neovascularization in drug therapy, photodynamic therapy, ocular surface reconstruction, etc. have done a lot of research and achieve rapid development. In this paper, the treatment of corneal neovascularization reviewed. Keywords: corneal neovascularization; treatment 0 Introduction Corneal neovascularization (corneal neovascularization, CNV) is a corneal inflammation and corneal rejection is closely related to a common pathological phenomenon. CNV infection cleared, wound healing, inhibit corneal dissolution, etc. have a certain effect, but it can damage the cornea to normal micro-environment, thus undermining the anterior segment physiological state of immune privilege, corneal transplant rejection is the high risk factors; new vascular structures are more fragile and easy to infiltration, often due to bleeding and exudation, and secondary fibrosis, leading to blindness, is one of the most common cause of blindness. In recent years, with research and development of new blood vessels at home and abroad for the study of CNV treatment of animal experiments and clinical trials are also carried out a large number, many of which showed a good clinical application prospect. 1 inhibited endothelial cell proliferation migration 1.1 angiostatin angiostatin (angiostatin, AS) was among the first acquired one of the endogenous angiogenesis inhibitor, which consists of plasminogen fragment kringles the first four hydrolytic fragments formed. AS cells by interfering with G2 / M over-inhibited endothelial cell proliferation and induce apoptosis of endothelial cells; AS and its receptor α / β-ATP synthase b