The pathogenesis of osteoarthritis and its relationship with Wnt - β-catenin signaling pathway.docVIP

 PAGE \* MERGEFORMAT 19 The pathogenesis of osteoarthritis and its relationship with Wnt / β-catenin signaling pathway [Abstract] [Objective] The Wnt / β-catenin signaling pathway in the pathogenesis of osteoarthritis in an important role. [Method] widely accessible in recent years about the pathogenesis of osteoarthritis literature, and summarize and analyze . [Results] osteoarthritis disease characterized by cartilage destruction and osteophyte formation accompanied by synovial lesions, recent studies confirm that Wnt / β-catenin signaling pathway in the pathogenesis of osteoarthritis plays a vital role . [Conclusion] Osteoarthritis is a joint effect of many risk factors for a progressive disease, Wnt / β-catenin signaling pathway in the pathogenesis of osteoarthritis plays a vital role. [Keywords:] cartilage destruction in osteoarthritis of Wnt / β-catenin signaling pathway Abstract: The recently published articles about the pathogenesis of osteoarthritis were reviewed.Osteoarthritis (OA) is characterized by cartilage degradation, osteophyte and involvement of the synovium.Mechanics, inflammatory mediators and aging collide studies in developmental, genetic and joint disease models indicate that Wnt / β-catenin signaling is critically involved in these processes.Many different factors contribute to the onset and progression of OA and Wnt / β-catenin signaling plays a vital role in these processes. Keywords:: osteoarthritis, cartilage; Wnt signaling Osteoarthritis (Osteoarthritis, OA) that affect human health, one of the most common joint disease, its incidence increases with age and higher. OA of the joint influence of all structure of [1,2]. Recent studies have confirmed that Wnt / β-catenin signaling pathway in OA plays a vital role in the pathogenesis [3]. In this paper, Wnt / β-catenin signaling pathway in the pathogenesis of OA important role in a brief review. Pathogenesis of osteoarthritis 1 1.1 The formation of osteoarthritis p