The pathogenesis of diabetic retinopathy Research Progress of VEGF and PEDF.docVIP

 PAGE \* MERGEFORMAT 32 The pathogenesis of diabetic retinopathy Research Progress of VEGF and PEDF Abstract Diabetic retinopathy (diabeic retinopathy, DR) is the most common and most serious diabetic microvascular complications, one of the basic pathological change is the blood - retinal barrier (blood retinal barrier, BRB) damage to the formation of new blood vessels. Neovascular membrane contraction pulling the late retinal detachment. The pathogenesis of DR is very complex and has not been fully clarified. Any pathological changes in the body, in essence, are dynamic balance disorders, the formation of new blood vessels Likewise, the vascular incentives to enhance and (or) reduce the inhibiting factors so that imbalance between the two so-called “angiogenic switch.” Vascular endothelial growth factor (vascuar endothelial growth factor, VEGF) and pigment epithelium-derived factor (pigment epithelium - derived factor, PEDF) as a vascular endothelial growth factor and vascular inhibitor of a typical representative, the role of diabetic retinopathy has been increasingly recognition. In this paper, both in diabetic retinopathy in the role of research to do a review. And for DR to provide ideas related to drug treatment. Keywords: Diabetic retinopathy; VEGF; PEDF Perspectives on VEGF and PEDF in the pathogenesis of diabetic retinopathy Abstract Diabetic retinopathy is one of the most frequently and the most severe micrangium complications of diabetes mellitus, the fundamental pathology characteristic of DR is breakdown of the blood-retinal barrier and neovascularization. In the later stage of DR, the formation of the epiretinal membrane, which may tractates the retina and produce detachment of the retina, results in progressive deterioration of vision. The pathogenesis is very complex and has not been elucidated completely. Retinal neovascularization results from both increasing of vascular stimulating factor and reducing of vascular i