The pathogenesis of acute pancreatitis in the role of tumor necrosis factor-Progress.docVIP

 PAGE \* MERGEFORMAT 11 The pathogenesis of acute pancreatitis in the role of tumor necrosis factor-Progress Keywords:: Acute pancreatitis with multiple organ failure and tumor necrosis factor (TNF-α ) With regard to occurrence of acute pancreatitis and its mechanism of multiple organ failure is still under study, in which the pre-inflammatory cytokines (including IL-1, IL-6, TNF-α ) in particular, TNF-α studies, to obtain a more significant progress, and has been applied to TNF-α antagonist to acute pancreatitis and multiple organ failure in the treatment of exploration. A tumor necrosis factor (TNF-α ) and acute pancreatitis and multiple organ failure in the relationship between the Clinical studies have demonstrated that serum of patients with acute pancreatitis pre-inflammatory cytokines (IL-1, IL-6, TNF) levels increased with the severity of the disease and ultimately the mortality rate was positively correlated, a number of animal experiments also confirmed that the serum pre-inflammatory cytokine concentration and the severity of acute pancreatitis, and in which TNF-α play a key role. Ogawa [1] observed in patients with pancreatitis serum levels of TNF-α in patients with pancreatitis prognosis and mortality. Christopher B [2] will be sterile mice by injection of artificial bile duct made of acute pancreatitis model in the control group injected only sterile saline. The results showed that sterile mice (213 ± 90 pg / ml), normal mice (181 ± 26.8 pg / ml) serum levels of TNF-α than the control group (24.6 ± 8.0 pg / ml) was significantly increased, while in the blood not detected bacterial endotoxin, indicating that TNF-α in the pathogenesis of pancreatitis in a separate work. Dolan S [3] in order to Wistar rats with bile duct injection of taurocholate pancreatitis model made of salt, and samples were taken at 2,3,12 hours detected TNF-α , the experimental group confirmed that TNF-α level higher than the control group significantly higher (P