Triglycerides and increase the renal toxicity in rats with adriamycin nephropathy preliminary study.docVIP

 PAGE \* MERGEFORMAT 33 Triglycerides and increase the renal toxicity in rats with adriamycin nephropathy preliminary study Author: Fu Peng Wei-Jie Yuan Yu Guoqing Yu-Guang Xu Jing CUI Ruo-lan [Abstract] Objective To study the triglyceride (TG) whether renal toxicity, as well as exogenous TG on adriamycin nephropathy in rats. Methods 40 male SD rats were divided into five groups, namely, C: normal control group, F Group: fructose-fed group, A Group: ADR nephropathy, FA Group: ADR nephropathy fructose fed group, FAB Group: ADR kidney fructose-fed group of fenofibrate treatment group (n = 10). Experimental period of 16 weeks. In the experiment before the experiment after 2,8 and 16 weeks respectively, fasting blood pumping check kidney function, albumin, blood lipids. Blood in urine test the next day to stay 24h urinary protein. Blood in urine when the left end of the experiment after the slaughter of animals, specimens from kidney tissues were observed under light microscope HE, oil red O staining pathological changes were measured kidney fibronectin (FN) and transforming growth factor β (TGF-β ) levels of . The results in rats fed fructose may result in a high prey TG hyperlipidemia, but basically no kidney disease, a rare kidney lipid deposition; while feeding fructose can significantly increase the blood of rats with adriamycin nephropathy TG levels, urinary protein excretion a marked increase in renal pathological changes aggravated glomerular and tubular increase in lipid deposition within the renal cortex FN and TGF-β levels than those with high prey hypertriglyceridemia in rats significantly increased or enhanced; while in Kyrgyzstan fibrozil lower plasma triglyceride levels in rats reduced urinary protein excretion and renal pathology reduced, significantly reduced lipid deposition within the kidney, renal cortex of FN and TGF-β decreased. Conclusion TG Hypertriglyceridemia on a SD rat kidney toxicity, and may increase the rats with adriamycin nephr