Triptolide against hematological malignancies Mechanisms.docVIP

 PAGE \* MERGEFORMAT 24 Triptolide against hematological malignancies Mechanisms Keywords: triptolide Triptolide (triptolide, TL) from the Celastraceae plant Tripterygium Tripterygium separated into two lactone compounds, and other structures compared to similar TWP, TL has a broader spectrum of anti-tumor, anti - cancer activity of the strongest features. TL significant in vivo and in vitro anti-mouse anti-human leukemia role of nasopharyngeal cancer, and may well inhibit human promyelocytic leukemia cell, T-cell lymphoma and human hepatocellular carcinoma growth, for lymphoma, melanoma, breast cancer, bladder cancer, stomach cancer, pancreatic cancer, cervical cancer, bile duct cancer and other cell lines or human tumor cell lines with significantly inhibit proliferation and promote apoptosis and control the transfer of role and with other chemotherapy drugs have anti-tumor synergy . ‘re On the blood system in recent years, TL anti-tumor mechanism to do a review. Biological characteristics of a TL isolated from Tripterygium containing a unique three-epoxy structure and a α, β-unsaturated a five-lactone ring abietane diterpenoid skeleton structure of three epoxy lactones. Appearance colorless needle-like crystal relative molecular weight of 360, molecular formula C2OH24O6, in vivo chemical stability, strong physiological activity. Soluble in dimethyl sulfoxide, acetone and other organic solvents. After oral or intravenous administration to the liver in vivo distribution of the highest concentrations, the half-life of about 2d. 14 C-OH, 3 epoxy groups, as well as a five-unsaturated lactone ring and other groups to play a variety of biological activities of its structural basis, under certain conditions, these groups with biological macromolecules (such as the regulation growth and the key enzymes of apoptosis) in the nucleophilic groups react, thereby inhibiting the function of these molecules play a TL anti-tumor effect.