Tumor necrosis factor-α on the regulation of lipid metabolism.docVIP

 PAGE \* MERGEFORMAT 13 Tumor necrosis factor-α on the regulation of lipid metabolism Abstract Tumor necrosis factor-α is a signaling molecule secreted by fat cells, one study suggests that tumor necrosis factor-α inhibit fatty acid intake of fat cells; reduce the key enzyme in fat, such as acetyl-CoA generated carboxylase, fatty acid synthase such as expression, the promotion of lipolysis, inhibit fat cell differentiation; tumor necrosis factor-α on fat cells and fat cells before the induction of apoptosis role. Keywords: tumor necrosis factor-α; lipid metabolism; fat cells Abstract: Tumor necrosis factor-alpha (TNF-α) is one of the messengers secreted by lipocytes.TNF-α can inhibit intake of fatty aicd in lipocytes, depress the expressions of aeetyl CoA carboxylase and fatty acid synthase; TNF-α inhibits differentiation of adipocytes and induces apoptosis of adipocytes and preadipocytes. Keywords:: tumor necrosis factor-alpha; lipid metabolism; adipocyte Adipose tissue in the body’s energy balance plays a fundamental role in the energy is sufficient, fat cells, the energy to fat (triglycerides) in the form of stored energy deficiency in the form of fat to free fatty acid mobilization out. There are three important lipid metabolism biochemical regulator sites, namely: fatty acid intake, fat and fat breakdown is generated [1]. These three factors on weight control are closely related. Tumor necrosis factor-α (tumor necrosis factor-alpha, TNF-α) is a signaling molecule secreted by fat cells, one study suggests that TNF-α involved in the regulation of fat cells in various aspects of physiological function, regulating glucose homeostasis, fatty acid metabolism and -induced insulin resistance. This paper analyzes the TNF-α on lipid metabolism in three important sites of biochemical regulation of TNF-α on adipocyte and lipid metabolism. 1 TNF-α inhibited fatty acid intake Fat cells from the circulation