Yin Jing cold particles of anti-influenza B virus Pharmacodynamic Study.docVIP

 PAGE \* MERGEFORMAT 14 Yin Jing cold particles of anti-influenza B virus Pharmacodynamic Study Author: Qiu Zhao Juan, ZHU Xuan-xuan, Ni Wen Peng, Yan Shihai, Qiong [Abstract] Objective To study the silver particles on Jing flu influenza B virus (B / Beijing, anti-98-96) in vivo. The cells were inoculated rat lungs adapted influenza B virus strains in the dog kidney cells (MDCK), observation of silver particles in vitro anti-viral flu Jing; ① in vivo in order to meet the influenza B virus strains of mice intranasally infected mice lungs were observed 14 d , calculate the survival rate and survival of mice the number of days; vivo experiments ② The influenza B virus strains of mice intranasally infected mice lungs to adapt to observe the lung index. Results dealbata cold particles in vitro anti-influenza B virus EC50 of 3.68 mg / ml. Yin Jing cold particles 10 g / kg and 20 g / kg dose group could significantly prolong the survival of mice infected with influenza B virus, the number of days and lower mortality; Yin Jing cold particles 20 g / kg dose group could significantly inhibit the lung index values, suppression rate was 36.7%. Conclusion Acacia dealbata flu influenza B virus particles on a certain extent. [Keywords:] Silver Jing flu influenza B virus particles in vivo inhibition Abstract: ObjectiveTo investigate the inhibitory effect of Yinjingganmao granule on Influenza B Virus. Methods The inhibitory cytopathic effects (CPE) of Yinjingganmao granule were observed by MDCK cell culture. The experiment in vivo were done by the following two methods: (1) The mice were given Yinjingganmao granule for 7 days and 30 μ l Influenza B Virus by nose at sequenti luce. We calculated the survival rate and days of mice 14 days later. (2) The mice were given intragastrically Yinjingganmao granule for 7 days and 30 μ l Influenza B Virus by nose at sequenti luce. We calculated the lung index and observed the pathological change. ResultsThe EC50 of Yinjingganmao gran