慢性HBV感染ALT持续正常与肝损伤的关系及其相关因素分析.pdfVIP

342 中国做化药物杂志 Chinese Jouma1 of 8iochemical Phannaceutics 2∞8 年第 29 卷第 5 期 ·临床· 慢性 HBV 感染 ALT 持续正常与肝损伤的关系及其相关因素分析 张岱1 ，正念跃2 (1.江苏大学基础医学与医学技术学院，江苏镇江 212013; 2. 东南大学医学院附属南京市第二医院 检验科，江苏南京 21 ∞03) 摘 襄:目的许估 ALT 持续正常的慢性阴阳V 感染者(PNA) 的肝脏损伤情况，探讨与其损伤相关的闲不，为临 床正确及时处理此桑患者提供参考。方法对符合研究标准的 lω 名慢乙肝患者，包括血清 ALT 水平持续正常的 53 例患者，按 ALT 水平分成4 绍，检测相关生化免疫等指标，同时做肝病或其F 刺，分析与肝损伤相关的阁索。结果 37.7% 的 PNA 患者有 S2 及以上等级的纤维化，45.3% 的 PNA 患者有 G2 月乱以上等级的炎症水平。年传越大，ALT 水 平越高，更高水平的 IIßV DNA 载登，有史严重的肝损伤。结论 53 例 PNA 患者中，43 .4%有明及纤维化或明显炎 症，对于 PNA 的使乙肝患者，大于 40 岁、ALT 25 u/L, HßV DNA 定受 1Q4/mL，尤其是男性患者，应考虑肝穿刺以 证实是否有肝损伤。 关键词:慢性 HßV 感染; ALT 持续正常;，@f损伤 中圈分类号:R446 文献标识码:A 文章编号:1005-1678(2∞8 )05-0342-03 Association between persistent normal ALT with chronic hepatitis B and liver injure as well as analysis of correlated factors 1 ZHANG Dai , WANG Nian-归e2 (1. Medical Technology School 0/Jiangsu Universíty , Zhenjíang 212013 , China; 2. 州1ιtjing AjJiliαted No .2 Hospital 0/ Medical SCMol 01 Southeast University , Na句iing 21 ω03 ， Chína) Abstract: Purpose To assess liver injury of these patients wîth chronic hepatitis B whose ALT are persis- lently normal , to explore these factors associated with Iiver i时u巧. and to provide choices when clínícians are treating those patients. Methods 160 palients meeting our inclusion crÍterÍa were divided Ínto four 伊uups ac翩 cording to their ALT. Multiply clinical , biochemical , immunological , virological índexes were collected , meanwhile , liver biopsy wωperformed. ResuIts 43 .4% of patients with PNA have significant illflammation anJ 17 . 1 % has si伊íficanl fibrosís. Olde