卡介菌多糖核酸联合特异性脱敏对支气管哮喘缓解期患者气道反应性及血清IgEIL.doc

KKME---专业医学搜索引擎/ 卡介菌多糖核酸联合特异性脱敏对支气管哮喘缓解期患者气道反应性及血清IgE、IL4的影响 　　作者：陈刚,林允信,闫保华,虎维东　　作者单位：江苏省南京市，南京军区73667部队门诊部(陈刚);甘肃省兰州市，兰州军区兰州总医院(林允信，闫保华，虎维东) 　　【摘要】目的 观察卡介菌多糖核酸(BCGPSN)联合特异性脱敏治疗(SIT)对支气管哮喘缓解期患者气道反应性的影响。 方法 选择支气管哮喘缓解期患者60例，随机分为3组，分别给予BCGPSN、SIT及BCGPSN+SIT(联合治疗组)治疗，并比较3组治疗后气道反应性、血清IgE及IL4水平的变化。 结果 联合治疗组治疗2月后气道反应性改善值△FEV1%由19.3±13.6增加至23.6±18.2,至3月时明显增加至32.7±18.8，此时血清总IgE仅轻度升高(317±363 kU/L),IL4水平显著降低(7.17±9.39 ng/L)，与单用BCGPSN和SIT组比较差异显著(P0.05或P0.01)。 结论 卡介菌多糖核酸与特异性脱敏联合治疗，可有效降低哮喘缓解期患者气道反应性，且减少体内炎性细胞因子释放。 　　【关键词】 支气管哮喘; 卡介菌多糖核酸; 特异性脱敏; 气道反应性; 白介素4 　　Influence of bcgpolysaccharide nucleinic acid with specific desensitization on airway reactivity,serum IgE and IL4 of bronchial asthmatic patients during the remission 　　CHEN Gang. Dutpatient Department, 73667 Troops of Nanjing Military, Nanjing 212421, China LIN Yungxin,YAN Baohua,Hu Weidong. General Hospital of Lanzhou Military, Lanzhou 730070，China 　　【Abstract】　Objective To observe the influence of bacillus calmete guerinpolysaccharide nucleinie acid combined specifie desensitization upon airway reactivity，blood serum IgE and IL4 of the bronchial asthmatic patients during the remission stage. Methods 60 cases of the bronchial asthmatic patients during the remission stage were selected and randomly divided into three groups, who were respectively given the treatment of bacilluscalmatte guerinPolyszccharide nucleinic acid,specifie desensitization and bacillus calmette guerinPolyszccharide nucleinic acid combined with specific desensitization (combined treatment group),and the changes in airway reactivity,serum IgE and IL4 were compared among these 3 groups. Results After a twomonth treatment, the airway reactivity improvement (△FEV1%)of the patients in the combined treatment group was increased (from 19.3±13.6 to 23.6±18.2),and this increasing was apparent in the third month (32.7±18.8),The total serum IgE level was slightly increased (317±363kUoL1),IL4 level was significantly reduc