Girdin蛋白与乳腺癌复发转移危险度的关系.pdfVIP

.70. 医学研究生学报2014 年 1 月第27 卷第1 期 ] Med pω， t/{ra ， Vol. 27 , No.1 , January , 2014 论著 (临A研究) Girdin 蛋白与乳腺癌复发转移危险度的关系 未明文，孙欣，林方才 [摘要] 目的 Girdin 蛋白在多种恶性肿瘤组织中处于高表达状态。文中探讨乳腺癌中 Girdin 蛋白的表达及其与术后复 发转移危险度的关系。 方法 采用免疫组化方法检测 Girdin 蛋白在65 例乳腺癌、27 例乳腺增生及30 例乳腺纤维腺瘤标本中 的表达水平，并根据2阳年St. Gallen 会议共识中的复发转移危险度将乳腺癌分为低危组、中危组和高危组。分析不同组别中 Girdin 蛋白表达的差异性。 结果 在乳腺癌组织中，Girdin蛋白的表达水平(40. ∞%)较乳腺增生组织(18.50% )及纤维腺瘤 组织(13.300毛)增高(P0.05) 。术后复发转移危险度高危组Girdin 蛋白阳性率高于中、低危组(PO. 臼)。 结论 Girdin 蛋 白高表达的患者，术后发生复发转移的危险度要高于低表达的患者。 Girdin 蛋白可能成为乳腺癌预后不良的指标之一。 [关键词] Girdin 蛋白;乳腺癌;复发转移 [中图分类号] R737.9 [文献标志码] A [文章编号] 1008-8199(2014)01-0070-03 Relationship between expression of girdin protein and risk of recurrence and metastasis in breast cancer ZHU Ming-wen , SUN Xin , LIN Fang-cai (Depαrtment 01 Genera1 Surgery , Electric p倒， Ier Teachi昭 Hospita1 Affiliated ω the Capita1 Medica1 University , Beijing 1(0073 , China) [Abstract] 0均创刊The expressions of Girdin in kinds 们mlignant tumor tissues are hi阱. The aim of this study is to inves- tigate the relationship between Girdin protein and risk of postoperative recu町ence and met副部is in breast cancer. Methods The ex- pression of Girdin protein in tbe breast specimens from 65 cases of breast cancer , 27 cases of breast hyperplasia specimens and 30 cases of breast fibroadenoma were exarnined by immunohistochemical staining. Breast cancer was divided into low risk group , intermediate risk group and high risk gro叩 according to risk categories in the 2α)7 St. Gallen conference consensus. 咀le Girdin protein expression in d证­ ferent groups were analyzed. Results Positive Girdin was higher in hreast cancer 40. ∞%由an in hreast hyperplasia 18.50% and fi- hroadenoma 13.300毛 (P 0.05). Positive rate of Girdin protein staining in high risk group was higher than in intermediate and low risk gro叩 (P 0.05). Conclusion P