Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a.docVIP

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Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a.doc

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Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a

BMC Genomics BioMedCentral Research article Open Access Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a Huan Nie?1,2, Fan Yang?2, Xiaobing Zhang?2, Jian Yang?2, Lihong Chen2, Jing Wang2, Zhaohui Xiong2, Junping Peng2, Lilian Sun2, Jie Dong2, Ying Xue2, Xingye Xu2, Shuxia Chen2, Zhijian Yao3, Yan Shen3 and Qi Jin*1,2,4 Address: 1College of Biological Sciences China Agricultural University, Beijing 100094, China, 2State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China, 3National Center of Human Genome Research, Beijing 100176, China and 4Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100730, China Email: Huan Nie - nh121212@; Fan Yang - ymf129@; Xiaobing Zhang - bbbzhang@; Jian Yang - yang@; Lihong Chen - chen@; Jing Wang - wwangjing@; Zhaohui Xiong - xiongsimon@163.com; Junping Peng - pengjp@; Lilian Sun - ll_sun@; Jie Dong - zhh@; Ying Xue - yylhu@; Xingye Xu - xyz810214@; Shuxia Chen - chenshuxia_2005@163.com; Zhijian Yao - yaozj@; Yan Shen - sheny@; Qi Jin* - zdsys@ * Corresponding author ?Equal contributors Published: 06 July 2006 Received: 28 February 2006 Accepted: 06 July 2006 BMC Genomics 2006, 7:173 doi:10.1186/1471-2164-7-173 This article is available from: /1471-2164/7/173 ? 2006 Nie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Shigella bacteria cause dysentery, which remains a significant threat to public health. Shigella flexneri is the most common species in both developing and developed countries. Five Shigella genomes have been sequenced, revealing dynamic and diverse features. To investigate the intra-species diversity of S. flexneri genomes further, we have