Constitutive Overexpression of Bcl-2, Survivin and ER Stress Chaperone GRP-78 Confers Intrinsic Radioresistance in Human Hepatocellular Carcinoma Cells Insight into the Mechanistic Pathways Involved.docVIP

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Constitutive Overexpression of Bcl-2, Survivin and ER Stress Chaperone GRP-78 Confers Intrinsic Radioresistance in Human Hepatocellular Carcinoma Cells Insight into the Mechanistic Pathways Involved.doc

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Constitutive Overexpression of Bcl-2, Survivin and ER Stress Chaperone GRP-78 Confers Intrinsic Radioresistance in Human Hepatocellular Carcinoma Cells Insight into the Mechanistic Pathways Involved

Journal of Cancer Therapy, 2013, 4, 399-407 399 /10.4236/jct.2013.42A048 Published Online February 2013 (/journal/jct) Constitutive Overexpression of Bcl-2, Survivin and ER Stress Chaperone GRP-78 Confers Intrinsic Radioresistance in Human Hepatocellular Carcinoma Cells: Insight into the Mechanistic Pathways Involved* Chih-Hsiung Wu , Yih-Huei Uen ,Chun-Te Ho , Ya-Ting Tseng , Tsan-Zon Liu , 1# 2,3# 4 5 6 6? 7? Jeng-Fong Chiou , Stephen Wan Leung 1 Department of Surgery, Taipei Medical University-Shuang Ho Hospital, Taipei, Chinese Taipei; Chi-Mei Foundation Medical Center, Tainan, Chinese Taipei; Departmento of Electrical Engineering, South Taiwan University, Tainan, Chinese Taipei; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Chinese Taipei; Graduate Insti- tute of Medical Biotechnology, Chang-Gung University, Gueishan, Chinese Taipei; Cancer Center and Department of Radiation Department of Radiology and Nuclear Medicine, Yuan’s 2 Department of General Surgery, 3 4 5 6 Oncology, Taipei Medical University and Hospital, Taipei, Chinese Taipei; General Hospital, Kaohsiung, Chinese Taipei. Email: 7 ? sjfchiou@, ? lawn@ Received December 18 , 2012; revised January 20 , 2013; accepted January 29 , 2013 th th th ABSTRACT We present evidence here that abundantly expressed ?-catenin-triggered NF-?B-dependent upregulation of inducible nitric oxide synthase (iNOS) found in hepatoma Mahlavu cells (RT-resistant variant designated as RR-Mal), but not in Hep 3B cells (RT-sensitive variant designated as RS-3B) is a key element contribrting to the radioresisitance thr