Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic.docVIP

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Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic.doc

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Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic

Pharmaceutics 2013, 5, 179-200; doi:10.3390/pharmaceutics5010179 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Article Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic Jeffrey S. Brown 1,2,*, Kenneth R. Petronis , Andrew Bate , Fang Zhang 1,2, Inna Dashevsky 1, 3 3 1 Martin Kulldorff 1,2, Taliser R. Avery , Robert L. Davis 2,4, K. Arnold Chan 5,6 , Susan E. Andrade 2,7, Denise Boudreau 2,8, Margaret J. Gunter 2,9, Lisa Herrinton 2,10 Pamala A. Pawloski 2,11, Marsha A. Raebel 2,12, Douglas Roblin 2,6, David Smith 2,13 and Robert Reynolds 3 , 1 Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA; E-Mails: fang_zhang@ (F.Z.); inna_dashevsky@ (I.D.); martin_kulldorff@ (M.K.); taliser_avery@ (T.R.A.) The HMO Research Network Center for Education and Research in Therapeutics; E-Mails: robert.l.davis@ (R.L.D.); susaneandrade@ (S.E.A.); boudreau.d@ (D.B.); mjgunt@ (M.J.G.); lisa.herrinton@ (L.H.); pamala.a.pawloski@ (P.A.P.); marsha.a.raebel@ (M.A.R.); douglas.roblin@ (D.R.); david.h.smith@ (D.S.) 2 3 Pfizer, Inc., New York, NY 10017, USA; E-Mail: kenneth.r.petronis@ (K.R.P.); andrew.bate@ (A.B.); robert.reynolds@ (R.R.) Kaiser Permanente Georgia, Atlanta, GA 30305, USA 4 5 6 7 OptumInsight, Waltham, MA 02451, USA; E-Mail: arnold.chan@ Harvard School of Public Health, Boston, MA 02115, USA Meyers Primary Care Institute, University of Massachusetts Medical School, the Meyers Primary Care Institute, Fallon Community Health Plan, Worcester, MA 01605, USA Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA Lovelace Clinic Foundation, Albuquerque, NM 87106, USA 8 9 10 11 12 13 Kaiser Permanente Northern California, Oakland, CA 94611, USA HealthPartners Research Foundation, Minneapolis, MN 55440, USA Kaiser Permanente Colorado, Denver, CO 8