Effect of Artocarpus communis Extract on UVB Irradiation-Induced Oxidative Stress and Inflammation in Hairless Mice.docVIP

Int. J. Mol. Sci. 2013, 14, 3860-3873; doi:10.3390/ijmOPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Effect of Artocarpus communis Extract on UVB Irradiation-Induced Oxidative Stress and Inflammation in Hairless Mice Chiang-Wen Lee 1,?, Horng-Huey Ko 2,?, Chee-Yin Chai , Wan-Tzu Chen , Chun-Ching Lin 4 3 3 and Feng-Lin Yen 2,* 1 Department of Nursing, Division of Basic Medical Sciences, Chronic Diseases and Health Promotion Research Center, Chang Gung Institute of Technology, Chia-Yi, Taiwan; E-Mail: cwlee@.tw 2 Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; E-Mail: hhko@.tw 3 Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; E-Mails: cychai@.tw (C.-Y.C.); wanzi@.tw (W.-T.C.) 4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; E-Mail: aalin@.tw ? These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: flyen@.tw; Tel.: +886-7-312-1101 (ext. 2028); Fax: +886-7-321-0683. Received: 15 October 2012; in revised form: 28 January 2013 / Accepted: 28 January 2013 / Published: 12 February 2013 Abstract: Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methanol extract of A. communis heartwood (ACM) in ultraviolet irradiation-induced skin damage has not yet been investigated. The present study was performed using ultraviolet absorption, histopathological observation, antioxidant and anti-inflammation assays to elucidate the mechanism of the photoprotective activity of ACM. Our results ind