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Effects of the platelet rich plasma on apexogenesis in young monkeys Radiological and hystologycal evaluation.doc

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Effects of the platelet rich plasma on apexogenesis in young monkeys Radiological and hystologycal evaluation

ActaVeterinaria(Beograd),Vol.62,No.1,39-52,2012. DOI:10.2298/AVB1201039P UDK591.84:616.073.7:616.314.165:611.018.52/54:599.824 EFFECTSOFTHEPLATELETRICHPLASMAONAPEXOGENESISINYOUNGMONKEYS: RADIOLOGICALANDHYSTOLOGYCALEVALUATION PETROVI]VANJA*,PEJ^I]NATA[A*,RAKI]MIA*,LEKOVI]V*,VASI]UNA**andSTOJI]@* *UniversityofBelgrade,SchoolofDentistry,Serbia **UniversityofBelgrade,FacultyofMedicine,Serbia (Received6thSeptember2011) Platelet-reachplasma(PRP)isanattractivetoolinregenerative medicineduetoitsabilitytostimulateproliferationanddifferentiationof stem cells. Since dental pulp derived stem cells are recognized as central in apexogenesis, the aim of the study was to evaluate radiologically and histologically effects of PRP on apexogenesis in teeth with immature roots. The study included eight monkeys (CercopithecusAethiops)dividedintwoequalgroupsforevaluation3 and 12 months after treatment. All participants obtained the same treatmentincludingpulpotomyandafter-treatmentwith:hydroxiapatite (HA)-incisor and HA+canine PRP. Radiological evaluation was performedusingthelongconeparallelingtechniqueforrecordingof defined parameters and histological evaluation was performed using tissueremovedenblockfortheobservationofparametersrelatedto apexogenesis. The results obtained radiologically and histologically haveshownincreaseinbridgeformationinHA+PRP(75%)groupafter 3 months comparing to HA group (50%). Contrary to that, after 12 monthstherewerenosignificantdifferencesbetweengroups.Theroot delaywasnotregisteredintheHA+PRPgroupcontrarytoHAgroup whereitwasregisteredin25%after12months.Resultsofthestudy suggest that PRP is a powerful tool for intensive and rapid apexogenesissinceitoffersclearandcomprehensiveresults(mostlyin thefirstthreemonths)whichareearlyradiologicallyvisiblewithoutany failureintheproposedrequests. Key words: apexogenesis, growth factors, hydroxyapatite, plateletrichplasma,PRP,regeneration INTRODUCTION Apexogenesisrepresentstheprocessofdevelopmentandformationof