Effects of some immunosuppressive factors on campylobacteriosis outbreaks in poultry.docVIP

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Effects of some immunosuppressive factors on campylobacteriosis outbreaks in poultry.doc

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Effects of some immunosuppressive factors on campylobacteriosis outbreaks in poultry

ActaVeterinaria(Beograd),Vol.58,No.2-3,167-177,2008. DOI:10.2298/AVB0803167S UDK619:612.017.12 EFFECTSOFSOMEIMMUNOSUPPRESSIVEFACTORSONCAMPYLOBACTERIOSIS OUTBREAKSINPOULTRY STOJANOVI*,MILI]N**,A[ANINRU@ICA**,VIDI]BRANKA*,NI[AVI]J**,GRGI]@* andPRICANADE@DA *ScientificVeterinaryInstituteNoviSad,NoviSad **FacultyofVeterinaryMedicine,UniversityofBelgrade (Received29.July2007) Campylobacteria are widely distributed in domestic and wild animals.Avianspeciesarethemostcommonhostofcampylobacteria, thusanimportantsourceforhumaninfectioncausedbythisorganism. Campylobacteriosis in animals frequently proceeds without clinical symptoms,whichmaybeduetothedifferentvirulenceoftheagent,as well as to the immune status of the infected animal. In this trial we investigatedtheeffectsofthevaccineagainstinfectivebursaldisease (IBD)onoccurrenceandclinicalmanifestationofcampylobacteriosis in conditions of controlled experimental infection with the strain Campylobacter jejuni. The immunosuppressive effects of a live attenuatedvaccineagainstIBDondevelopmentofclinicallymanifest campylobacteriosisinperorallychallengedchickenswereassessed. The investigation was performed on 90 chickens in experimental conditions.ThepresenceofCampylobacterjejuniwasconfirmedbyre- isolation, while identification of the organism was performed on the basis of its morphological, cultural and biochemical characteristics. Specific antibody titer and humoral immune response to C. jejuni specific antibodies were monitored using the complement fixation reactionmethod.Clinicalsymptomsofthediseasewereobservedin chickens infected with Campylobacter jejuni and vaccinated against infective bursal disease. Pathomorphological findings revealed changes in the intestines and liver, from which Campylobacter jejuni wasisolated.C.jejunispecificantibodiesweredetectedintheinfected birdsinthethirdweekpostinfection,withtitervaluesrangingfrom1:4 to1:16.Resultsofourresearchstronglyimplyanimmunosuppressive effectoftheIBDvaccineondevelopm