Anticancer Effect in HL-60 Human Leukemia Cells and Other Helath-Beneficial Functions of Cheese.docVIP

Open Journal of Blood Diseases, 2013, 3, 7-10 7 /10.4236/ojbd.2013.33A002 Published Online October 2013 (/journal/ojbd) Anticancer Effect in HL-60 Human Leukemia Cells and Other Helath-Beneficial Functions of Cheese Shin Yasuda, Keiji Igoshi Department of Bioscience, School of Agriculture, Tokai University Aso Campus, Kumamoto, Japan. Email: shin.yasuda@agri.u-tokai.ac.jp Received August 7 , 2013; revised September 7 , 2013; accepted September 15 , 2013 th th th Copyright ? 2013 Shin Yasuda, Keiji Igoshi. This is an open access article distributed under the Creative Commons Attribution Li- cense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT With regard to the aim of cancer prevention and/or treatment, a considerable number of basic studies have indicated that dairy and other plant-originated natural food products may possess anticancer activity. On the growth of human leuke- mia cells, for example, enzymatically digested skim milk or fermented milk cultured with various bacteria can exhibit differential suppressive activities. Our research team has previously revealed that highly ripened cheese was capable of demonstrating strong growth inhibition and induction of apoptotic DNA damage on HL-60 human promyelocyticleu- kemia cells. In this short review, the available information concerning potent anticancer effects of cheese was summa- rized. From the stand point of Food Science, functional implications for cancer prevention as well as multifaceted func- tion of cheese are discussed. Keywords: HL-60; Leukemia; Antiproliferation; Anticancer; Cheese; Food Function 1. Introduction a model. The HL-60 cell line established in 1977 from a patient with acute myeloid leukemia [11], was chosen because of a valid an