Childhood Maltreatment Is Associated with Larger Left Thalamic Gray Matter Volume in Adolescents with Generalized Anxiety Disorder.docVIP

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Childhood Maltreatment Is Associated with Larger Left Thalamic Gray Matter Volume in Adolescents with Generalized Anxiety Disorder.doc

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Childhood Maltreatment Is Associated with Larger Left Thalamic Gray Matter Volume in Adolescents with Generalized Anxiety Disorder

ChildhoodMaltreatmentIsAssociatedwithLargerLeft ThalamicGrayMatterVolumeinAdolescentswith GeneralizedAnxietyDisorder MeiLiao1,FanYang1,YanZhang1,ZhongHe2,MingSong3,TianziJiang3,ZexuanLi1,ShaojiaLu1, WeiweiWu1,LinyanSu1*,LingjiangLi1* 1Department of Psychiatry, the Second Xiangya Hospital of Central South University, Changsha, China, 2Department of Radiology, the Second Xiangya Hospital of CentralSouthUniversity,Changsha,China,3NationalLaboratoryofPatternRecognition,InstituteofAutomation,ChineseAcademyofSciences,Beijing,China Abstract Background: Generalized anxiety disorder (GAD) is a common anxiety disorder that usually begins in adolescence. Childhood maltreatment is highly prevalent and increases the possibility for developing a variety of mental disorders includinganxietydisorders.AnearlierageatonsetofGADissignificantlyrelatedtomaltreatmentinchildhood.Exploring the underpinnings of the relationship between childhood maltreatment and adolescent onset GAD would be helpful in identifyingthepotentialriskmarkersofthiscondition. Methods: Twenty-six adolescents with GAD and 25 healthy controls participated in this study. A childhood trauma questionnaire (CTQ) was introduced to assess childhood maltreatment. All subjects underwent high-resolution structural magneticresonancescans.Voxel-basedmorphometry(VBM)wasusedtoinvestigategraymatteralterations. Results:SignificantlylargergraymattervolumesoftherightputamenwereobservedinGADpatientscomparedtohealthy controls.Inaddition,asignificantdiagnosis-by-maltreatmentinteractioneffectfortheleftthalamicgraymattervolumewas revealed, as shown by larger volumes of the left thalamic gray matter in GAD patients with childhood maltreatment compared with GAD patients without childhood maltreatment as well as with healthy controls with/without childhood maltreatment.Asignificantpositiveassociationbetweenchildhoodmaltreatmentandleftthalamicgraymattervolumewas onlyseeninGADpatients. Conclusions:Thesefindingsrevealedanincreasedvolumeinthesu