Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice.docVIP

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Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice.doc

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Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

ChronicRestraintStressInhibitsHairGrowthvia SubstancePMediatedbyReactiveOxygenSpeciesin Mice NanLiu1.,Lin-HuiWang2.,Ling-LingGuo3.,Guo-QingWang2,Xi-PingZhou2,YanJiang2,JingShang4, KojiMurao5,Jing-WeiChen6,Wen-QingFu1*,Guo-XingZhang2* 1DepartmentofClinicalPsychology,MedicalCollegeofSoochowUniversity,Suzhou,P.R.China,2DepartmentofPhysiology,MedicalCollegeofSoochowUniversity, Suzhou, P.R. China, 3Department of Pathology, Medical College of Soochow University, Suzhou, P.R. China, 4New Drug Screening Center, China Pharmaceutical University,Nanjing,P.R.China,5DepartmentofClinicalLaboratory,FacultyofMedicine,KagawaUniversity,Kita-gun,Kagawa,Japan,6DepartmentofInternalMedicine, SuzhouChineseTraditionalMedicineHospital,Suzhou,P.R.China Abstract Backgrounds: Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP) mediated immune response, the role of reactive oxygen species (ROS) in brain-skin-axis regulationsystemremainsunknown. Objectives:ThepresentstudyaimstoinvestigatepossiblemechanismsofROSinregulationofSP-mastcellsignalpathway inchronicrestraintstress(CRS,amodelofchronicpsychoemotionalstress)whichinducedabnormalofhaircycle. MethodsandResults:OurresultshavedemonstratedthatCRSactuallyalteredhaircyclebyinhibitinghairfolliclegrowthin vivo, prolonging the telogen stage and delaying subsequent anagen and catagen stage. Up-regulation of SP protein expressionincutaneousperipheralnervefibersandactivationofmastcellwereobservedaccompaniedwithincreaseof lipidperoxidationlevelsandreductionoftheactivitiesofsuperoxidedismutase(SOD)andglutathioneperoxidase(GSH-Px) inCRSmiceskin.Inaddition,SPreceptorantagonist(RP67580)reducedmastcellactivationsandlipidperoxidationlevelsas wellasincreasedGSH-Pxactivityandnormalizedhaircycle.Furthermore,antioxidantTempol(afreeradicalscavenger)also restoredhaircycle,reducedSPproteinexpressionandmastcellactivation. Conclusions:OurstudyprovidesthefirstsolidevidenceforhowROSplayarole