Comparison of Sequencing Platforms for Single Nucleotide Variant Calls in a Human Sample.docVIP

ComparisonofSequencingPlatformsforSingle NucleotideVariantCallsinaHumanSample AakroshRatan1.,WebbMiller1,JosephGuillory2,JeremyStinson2,SomasekarSeshagiri2, StephanC.Schuster1*. 1CenterforComparativeGenomicsandBioinformatics,PennsylvaniaStateUniversity,UniversityPark,Pennsylvania,UnitedStatesofAmerica,2DepartmentofMolecular Biology,GenentechInc.,SouthSanFrancisco,California,UnitedStatesofAmerica Abstract Next-generation sequencings platforms coupled with advanced bioinformatic tools enable re-sequencing of the human genomeathigh-speedandlargecostsavings.WecomparesequencingplatformsfromRoche/