Tyrosine kinase signalling in breast cancer Insulin-like growth factors and their receptors in breast cancer 英文论文文献.docVIP

/content/2/3/170 Review Tyrosine kinase signalling in breast cancer Insulin-like growth factors and their receptors in breast cancer Xihong Zhang and Douglas Yee University of Minnesota Cancer Center, Minneapolis, Minnesota, USA Received: 8 December 1999 Accepted: 21 February 2000 Published: 16 March 2000 Breast Cancer Res 2000,2:170–175 ? Current Science Ltd Abstract The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon ac